Research progress of MMP-7 in non-small lung cancer / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 93-96, 2016.
Article
in Zh
| WPRIM
| ID: wpr-499327
Responsible library:
WPRO
ABSTRACT
Lung cancer is one of the most common malignant tumors in the world.Non-small lung canc-er( NSCLC) accounts for approximately 85%,but its pathogenesis has not been elucidated.As a family of soluble enzymes,matrix metalloproteinases(MMPs)can degrade the constituents of the extracellular matrix(ECM)and the basement-membrane,members share common structural features and are responsible for the relative specific sub-strates.Some researches show that the matrix metalloproteinases 7(MMP-7)involve in the invasion and metasta-sis of NSCLC,the expression of MMP-7 in the tissue of NSCLC is significcantly higher than that in adjacent tis-sues,and the MMP-7 plays important roles in prognosis evaluation of NSCLC patients.Therefore this paper sum-marize the domain structure,function,regulation and research in NSCLC about MMP-7.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Practical Oncology Journal
Year:
2016
Document type:
Article