Changes of TIZ expression in epithelial ovarian cancer cells
Asian Pacific Journal of Tropical Biomedicine
; (12): 157-161, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-500539
Responsible library:
WPRO
ABSTRACT
Objective:
To study the change ofTIZ expression in epithelial ovarian cancer cells.Methods:
HO8910 cells were transinfected with siRNA to inhibit the expression ofTIZ. pcDNA3.1-TIZ vectors were combined to increase theTIZ expression level.The cell viability, colony forming efficiency and cycle distribution ofHO8910,HO8910/NC,HO8910/pcDNA3.1-NC,HO8910/TIZ-573 andHO8910/pcDNA3.1-TIZ were compared, and the invasion rate, migration rate and adhesion rate between5 groups of cells were compared.Results:
Compared with those ofHO8910,HO8910/NC andHO8910/pcDNA3.1-NC, the cell viability, colony forming efficiency and cell cycle distribution ofHO8910/TIZ-573 were increased, while the indexes ofHO8910/pcDNA3.1-NC were decreased with statistical significant difference(P0.05).Conclusions:
The expression ofTIZ can inhibit the proliferation of epithelial ovarian cancer cells.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2015
Document type:
Article