Therapeutic Efficacy and ADR Evaluation of Amphotericin B in the Treatment of AIDS Complicating with Fungal Infections / 中国药房
China Pharmacy
; (12): 3238-3240, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-500997
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To evaluate therapeutic efficacy and ADR of amphotericin B in the treatment of AIDS combined with fungal infections retrospectively.METHODS:
The cases of amphotericin B in the treatment of AIDS combined with fungal in-fections were collected our hospital. Total therapeutic efficacy,distribution of pathogenic bacteria,clearance rate and ADR were evaluated.RESULTS:
89 patients were involved totally,among which 45 cases were marked effect,32 cases improved and 12 cas-es failed,with effective rate of 86.5%. The fungus were found or cultured in 76 cases,among which 64 strains were cleared,but 12 strains were not,with total clearance rate of 84.2%. There were 41 ADR cases(46.1%),while all completed the treatment ex-cept 2 developing severe renal failure(2.2%).CONCLUSIONS:
Domestic amphotericin B could effectively treat AIDS complicat-ing with fungal infections,and the ADRs were acceptable.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Document type:
Article