Determination of Release Rate and in vitro Transdermal Rate of Asarinin in Cancer Pain Cataplasm / 中国药房
China Pharmacy
; (12): 482-484, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-501411
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To determinate the release rate and in vitro transdermal rate of asarinin in Cancer pain cataplasm.METHODS:
Using homemade devices and modified France diffusion,isolated skin of rats as barrier,normal saline as solvent,the content of asarinin was determined by HPLC. Release rate of Cancer pain cataplasm within 20,50,80 and 120 min and transder-mal amount within 2,4,8,12,24 h were investigated,and accumulative release rate and accumulative transdermal rate were cal-culated.RESULTS:
Accumulative release rate by 120 min of asarinin in Cancer pain cataplasm was 73.01%;24 h in vitro transder-mal rate was 26.01%,and transdermal kinetics equation of asarinin was Q=5.717 7t1/2-0.385 4(r=0.979).CONCLUSIONS:
Cancer pain cataplasm has good release and transdermal performance. Its transdermal kinetics is in line with Higuchi equation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Document type:
Article