Effect of CYP4F2 Gene Polymorphism on Warfarin Maintenance Dose in Chinese Population:a Systematic Review / 中国药房
China Pharmacy
; (12): 3803-3805, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-502695
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To systematic review the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population,and to provide evidence-based reference for clinical treatment.METHODS:
Retrieved from Cochrane library,PubMed,EMBase,CJFD,VIP and Wanfang database,studies about the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population were collected,and Meta-analysis was performed by using Rev Man 5.0 statis-tics software.RESULTS:
A total of 13 studies were included,involving 2 958 patients. The type of gene was type TT,type CT and type CC. Results of Meta-analysis showed the relationship between 3 gene polymorphism and warfarin maintenance dose was type TT>type CT>type CC,and there were significant differences among groups.CONCLUSIONS:
CYP4F2 gene polymorphism in Chinese population has significant correlation with warfarin maintenance dose. However,due to the limit of methodological quali-ty,large-scale and high quality studies are required for further validation of the conclusions.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Systematic review
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Document type:
Article