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Preparation and Evaluation of Triptolide Self-microemulsifying Drug Delivery System / 中国药师
China Pharmacist ; (12): 638-642, 2017.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-511697
Responsible library: WPRO
ABSTRACT

Objective:

To study the formula of triptolide (TRI) self-microemulsifying drug delivery system (SMEDDS) and evaluate the pharmaceutical properties.

Methods:

The formula and preparation process of triptolide self-microemulsion were screened by the solubility test and pseudo-ternary phase diagram.With the average particle size and self-microemulsifying time as the indices,the further formula optimization of triptolide self-microemulsion was carried out.The pharmaceutical properties of triptolide self-microemulsion were evaluated.

Results:

The optimal formula of TRI SMEDDS was as followsthe amount of medium chain triglycerides (MCT) was 20%,that of polyoxyethylene castor oil (EL-35) was 40%,and that of polyethylene glycol 400 (PEG-400) was 40% in the oil phase.The average particle size was 43.48 nm,and the time of self-microemulsification was less than 30 s.

Conclusion:

The average particle size and the appearance of triptolide self-microemulsion are accordance with the requirements of pharmaceutics.Triptolide self-microemulsion has good sustained-release effect,which lays foundation for the further study on pharmacodynamics.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2017 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2017 Document type: Article
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