Advance and application of CRISPR/ Cas9 mediated genome editing technique on pathogenic microorganism / 中国人兽共患病学报
Chinese Journal of Zoonoses
; (12): 280-286, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-513200
Responsible library:
WPRO
ABSTRACT
Clustered regularly interspaced short palindromic repeats (CRISPR) is an acquired immune system existing in archaea and bacteria with the long-term process of evolutionary.CRISPR/Cas9 gene editing system is a new type of gene editing technology developed based on the system.CRISPR/Cas9 is a more efficient method for gene targeting than the previous methods.It has been successfully applied for gene-modified of eukaryotes since 2012,but the reports about pathogenic microorgaisms are rarely.Here,the research progress in the structure,mechanism of CRISPR/Cas9 system and its applications on pathogenic microorgaisms is reviewed.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Zoonoses
Year:
2017
Document type:
Article