The Role of FUS/TLS in the Regulation of Gene Expression and the Correlation with Neurodegenerative Diseases / 昆明医科大学学报
Journal of Kunming Medical University
; (12): 1-4, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-514180
Responsible library:
WPRO
ABSTRACT
Neurodegenerative diseases are chronic lesions caused by neuronal degeneration and secondary demyelination.Recent studies have shown that a DNA/RNA binding protein named fused in sarcoma/translocated in liposarcoma protein (FUS/TLS) is associated with neurodegenerative diseases,such as amyotrophic lateral sclerosis (ALS),frontotemporal dementia (FTD) and polyglutamine diseases.Mutations or dysfunction in FUS/TLS are responsible for the abnormal processes in the related gene transcription,RNA processing,transportation and translation and are highly correlated with the development of neurodegenerative disease.Discovery and the research of FUS/TLS not only contribute to the understanding of neurodegenerative disease at RNA level,but also provide a new way for the prevention and treatment of neurodegenerative diseases.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Kunming Medical University
Year:
2016
Document type:
Article