Study on Compatibility Stability of Ulinastatin for Injection with 2 Commonly Used Solvents in the Infusion Pump / 中国药房
China Pharmacy
; (12): 1041-1044, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-514936
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the compatibility stability of Ulinastatin for injection with 2 commonly used solvents in the infusion pump.METHODS:
After Ulinastatin for injection 500 000 U was respectively added into 0.9% Sodium chloride injection and 5% Glucose injection 50 mL,the appearance of the mixture at 25 ℃,37 ℃ were observed at 0,1,2,4,8,12,24 h,re spctively,pH value and the number of insoluble particles were measured.The relative percentage of ulinastatin in the mixture was determined by HPGFC.RESULTS:
Under this condition,the appearance and pH value of the mixture had no significant change within 24 h;the number of particles ≥10 μm was lower than 25 particle/mL,and that ≥25 μm was lower than 3 particle/mL,which was in line with the pharmacopeia standard.The relative percentage of ulinastatin within 24 h ranged 99.45%-102.55%.CONCLUSIONS:
After mixed with 0.9% Sodium chloride injection and 5% Glucose injection,Ulinastatin for injection keep stable within 24 h at 25 ℃,37 ℃ and can be used for continuous administration in the infusion pump.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Document type:
Article