Spasmolytic Effects of an Extract from Coleus Forskohlii on Airway Smooth Muscles / 昆明医科大学学报
Journal of Kunming Medical University
; (12)1988.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-515801
Responsible library:
WPRO
ABSTRACT
An extract isolated from Coleus forskohlii contains 1, 7—diacetyl—forskolin, which is similar to forskolin in chemical structure and biological activity. The relaxant effects of the extract and aminophylline were compared on isolated guinea pig parenchymal strips and tracheal spirals. The contractions induced by submaximal dose histamine (l?g/ ml) were antagonized by both the extract and aminophylline in doseresponse relevance. (IC_(50)5, 5?1.4?g/ ml and 0.8? 0.4mg/ ml respectively.) The antiasthmatic potency of the extract was 145 time that of aminophylline. comparing with aminophylline, the acute toxicity of the extract was lower.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Kunming Medical University
Year:
1988
Document type:
Article