Relation between urinary protein excretion and oxidation and antioxidation in rats with passive Heymann nephritis / 中国病理生理杂志

ABSTRACT

In order to understand the effect of oxidant and antioxidant on proteinuriaformation of rats with passive Heymann nephritis (PHN), vitamin E (VitE), malondialde-hyde (MDA), xanthine oxidase (XOD) in serum and urine, and 24 hours protein excretionin urine were measured. The results showed that in both rats of heterologous phase (day7) and autologous phase (day 14), MDA in serum and urine, VitE and, 24 h pro-tein excretion in urine were all markedly increased, while VitE in serum was significantlydecreased, however the XOD level in serum and urine were not much altered. Correlationanalysis revealed that there were positive correlation between the amount of urinary pro-tein and that of MDA in serum and urine, and also between that of urinary protein andVitE in urine. A negative correlation existed between the amount of urinaryprotein andVitE level in serum. These results suggested that in rats with PHN there be an hyper-lipidperoxchtion with an pypo-anti-oxidation.