Urinary Sodium Excretion Has Positive Correlation with Activation of Urinary Renin Angiotensin System and Reactive Oxygen Species in Hypertensive Chronic Kidney Disease
Journal of Korean Medical Science
; : S123-S130, 2014.
Article
in En
| WPRIM
| ID: wpr-51700
Responsible library:
WPRO
ABSTRACT
It is not well described the pathophysiology of renal injuries caused by a high salt intake in humans. The authors analyzed the relationship between the 24-hr urine sodium-to-creatinine ratio (24HUna/cr) and renal injury parameters such as urine angiotensinogen (uAGT/cr), monocyte chemoattractant peptide-1 (uMCP1/cr), and malondialdehyde-to-creatinine ratio (uMDA/cr) by using the data derived from 226 hypertensive chronic kidney disease patients. At baseline, the 24HUna/cr group or levels had a positive correlation with uAGT/cr and uMDA/cr adjusted for related factors (P or =200 mEq/g cr was higher than in patients with or =200 mEq/g cr (P=0.016). During the 16-week follow-up period, an increase in urinary sodium excretion predicted an increase in urinary angiotensinogen excretion. In conclusion, high salt intake increases renal renin-angiotensin-system (RAS) activation, primarily, and directly or indirectly affects the production of reactive oxygen species through renal RAS activation.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Renin-Angiotensin System
/
Sodium, Dietary
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Angiotensinogen
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Demography
/
Follow-Up Studies
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Reactive Oxygen Species
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Chemokine CCL2
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Creatine
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Renal Insufficiency, Chronic
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Urine Specimen Collection
Type of study:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2014
Document type:
Article