Role of angiotensin Ⅱ on type Ⅰcollagen synthesis and its mRNA expression in vascular adventitial fibroblasts / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-517010
Responsible library:
WPRO
ABSTRACT
AIM:
Effects of anatotensin Ⅱ on type Ⅰ collagen synthesis and its mRNA expansion in cultured vascular adventitial fibroblasts.METHODS:
Vascular adventitial fibroblasts (VAF)were isolated, cultured from rat thoracic aorta by explant method. ELISA was used to study type Ⅰ collagen synthesis and competihve RT - PCR was employed to detect its mRNA expression after angiotensin Ⅱ administration.RESULTS:
Angiontensin Ⅱ caused a dose dependent increase of type Ⅰ collagen synthesis and its mRN expression in VAF.CONCLUSION:
The results support that angiotensin Ⅱ is an important factor controlling collagen metabolism of VAF and VAF may play an im- portant role in vascular remodelling of hypertension.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1989
Document type:
Article