Restricted expansion of T cell receptor (TCR)V? genes in leukemic patients subjected to allogeneic hematopoeitic stem cell transplantation / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1986.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-517642
Responsible library:
WPRO
ABSTRACT
AIM:
To investigate restricted expansion of TCR V? gene repertoire in patients with leukemia following allogeneic hematopoietic stem cell transplantation.METHODS:
TCR V? subfamily genes in peripheral blood mononuclear cells from 7 cases of leukemia was amplified using RT-PCR.RESULTS:
Only two-eight fragments of V? genes were detected in samples from these patients, and the detected fragments are different in different patients.CONCLUSION:
TCR complexes were abnormal in all patients, part of the genes were seletively expansed and part of them were suppressed after transplantation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Document type:
Article