The damages of adrenal gland in rabbits with neisseria memingococcal septic shock / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-517797
Responsible library:
WPRO
ABSTRACT
AIM:
To investigate the damages of adrenal gland in rabbits infected with neisseria meningococci(MC).METHODS:
18 rabbits were injected with MC (1?10 11 organism/kg, iv, model group, n=10 ) or normal saline (control group, n=8 ).TNF-? was detected in baseline (before challenged), 60 min and 120 min after injection. 120 min after injection, TNF-? immunochemical localization of adrenal gland was detected with ABC methods by electron microscopy.RESULTS:
In model group, TNF-? positive cells were located in medulla and TNF-? released into simus of medulla. The medulla damages were appeared but gland cells of cortex was normal. No damages were showed in control group. TNF-? value of plasm was elevated at 60 min and 120 min after injection compared with control group.CONCLUSION:
TNF-? was released into medulla and resulted in medulla damages after MC challenging. Adrenal cortex didnt damaged in early phase of MC septic shock. [
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1989
Document type:
Article