A study on the relationship between serum cytokine levels and clinical manifestation in colorectal cancer patients / 中国普通外科杂志

ABSTRACT

Objective To investigate the Th1/Th2 imbalance, defective cell medicated anti tumor response and the relationship between cytokine levels and clinicopathologic findings in colorectal cancer patients.Methods 62 colorectal cancer patients and 15 volunteers were recruited for the study. Peripheral blood samples were collected to detect IL 2, IL 6, IL 10, IL 12, TNF levels and NK activity, proportions of CD3 + , CD4 + ,CD8 + T cells.Results Patients with colorectal cancer had decreased levels of IL 2, IL 12 and elevated levels of IL 6, IL 10 compared to controls( P