Protective effect of onychin on the human umbilical vein endothelial cells injured by menadione / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1986.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-520272
Responsible library:
WPRO
ABSTRACT
AIM:
To investigate the protective effect of onychin on the endothelial cells injured by oxidative stress.METHODS:
The injured model was established by endothelial cells treated with menadione. The growth inhibitory rate of endothelial cell was determined by MTT assay; NO - 2/NO - 3 concentration in the medium was determined by nitrate reductase assay; eNOS and caveolin-1 protein levels were determined by Western blot.RESULTS:
Onychin significantly decreased the growth inhibitory rate of endothelial cells injured by menadione, increased NO - 2/NO - 3 concentration in the medium and eNOS activity and up-regulated caveolin-1 expression.CONCLUSION:
Onychin possesses a protective effect against endothelial cell injury induced by menadione via caveolin-1/eNOS pathway.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Document type:
Article