Study on Formulations and in Vitro Drug Release of Sustained-release Bioadhesive Danazol Suppository / 中国药房
China Pharmacy
; (12)1991.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-520764
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To screen the formulations of bioadhesive danazol suppository,and to study its drug release in vitro.METHODS:
Hydroxypropyl methylcellulse(HPMC),polyethylene glycol(PEG)6000and PEG600were employed in the bioadhesive sustained-release formulation.Suppositories were prepared and the correlation between drug release rate from suppositories and the ratio of HPMC to PEGs used in the formulae was studied.RESULTS:
HPMC retarded drug release,and drug gradually released in the12-hours period when the ratio of HPMC to PEGs was1∶6.5;the law of drug release was conformed to weibull models and mono-exponential models.CONCLUSION:
HPMC,PEG6000and PEG600were suitable to the formulation of bioadhesive danazol suppositories,and HPMC could slow down the drug release from the this preparation;the best ratio of HPMC to PEGs was1∶6.5.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Document type:
Article