Effects of Shuanghuanglian on Pharmacokinetics of Theophylline in Healthy Subjects / 中国药房
China Pharmacy
; (12)2001.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-521437
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To study the effects of Shuanghuanglian on pharmacokinetics of theophylline in healthy sub?jects.METHODS:
The serum concentration of theophylline was determined by HPLC and analyzed by3p97pharmacokinetic program.RESULTS:
The main pharmacokinetic parameters of single theophylline and that in combined use with Shuanghuan?glian were as followsT max were(1.66?0.56)and(1.59?0.78)h,C max were(6.23?1.31)and(6.10?0.94)?g/ml,T 1/2 were(5.76?1.11)and(6.09?1.63)h,CL were(47.72?5.12)and(50.98?10.85)ml/(kg?h),Vd were(369.18?40.15)and(430.37?48.33)ml/kg,AUC 0~∞ were(84.56?14.43)and(89.27?26.35)?g/(h?ml),respectively.CONCLUSION:
The Vd of theophylline were increased(P
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Document type:
Article