Expression of Membrane Type 1 Matrix Metalloproteinase and Matrix Metalloproteinase-2 in Cutaneous Squamous Cell Carcinoma and Basal Cell Epithelioma / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12)2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-523378
Responsible library:
WPRO
ABSTRACT
Objective To observe expression of membrane-type 1 matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) and its relation to clinicopathological characteristics in cutaneous squamous cell carcinoma (SCC) and basal cell epithelioma (BCE). Methods The expression of MT1-MMP and MMP-2 was determined in situ hybridization and ABC immunohistochemical technique respectively in 48 cutaneous SCCs and 41 BCEs. Results The expression of MT1-MMP and MMP-2 in SCC was significantly higher than that in BCE (P 0.05). Conclusions Overexpression of MT1-MMP and MMP-2 might be related to lymphatic metastasis in SCC. Expression levels of MT1-MMP and MMP-2 may not be responsible for the differentiation in aggressiveness of BCE.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
2003
Document type:
Article