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Effect of ovariectomization on Alzheimer-like phosphorylation of Tau in hippocampus of rats / 中国病理生理杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-523809
Responsible library: WPRO
ABSTRACT

AIM:

To explore the effect of ovariectomization on Alzheimer-like phosphorylation of Tau in hippocampus of Sorague-Dawlery rats.

METHODS:

An animal model was developed using ovariectimized (OVX) rats, and the phosphorylation of Tau protein was measured by Western blot.

RESULTS:

The levels of phosphorylated Tau at PHF-1epitope were elevated in ovariectimized rat brain hippocampus 4 weeks and 8 weeks after ovariectomization, when compared with sham-OVX rats (P0.05).

CONCLUSION:

Ovariectomization may induce Alzheimer-like hyperphosphorylation of Tau protein in brain hippocampus of rats. [

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 2000 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 2000 Document type: Article
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