Effect of ERK1/2 on ischemic preconditioning in diabetic rat hearts / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1986.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-524078
Responsible library:
WPRO
ABSTRACT
AIM:
To test the effect of ERK1/2 on ischemic preconditioning (IPC) in diabetic rat hearts.METHODS:
The diabetic rat model was made with alloxan. After eight weeks, 24 rats were divided into 4 groups non-diabetic IPC rats (group A); non-diabetic non-IPC rats (group B); diabetic IPC rats (group C); diabetic non-IPC rats (group D). ECGⅡ lead, left ventricular development pressure (LVDP), and first derivative of LVDP ~(?dp/dt_~max ) were recorded. Myocardial phosphorylation of extracellular signal regulated kinases1/2 (ERK1/2) was detected by Western-blotting.RESULTS:
(1) The ventricular arrythmia score was significantly lower in group A than that in group C (P
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Document type:
Article