Determination of the Riluzole Concentration in Blood Plasma by RP-HPLC / 中国药房
China Pharmacy
; (12)1991.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-524114
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To develop the method for the determination of riluzole concentration in blood plasma.METH?ODSRiluzole was extracted with diethyl ether.The residues were analyzed with a reverse phase HPLC system(Diamonsil TM C 18 column,250mm?4.6mm,5?m),with mobile phase of MeOH-0.03mol/L and NH 4 H 2 PO 4 (80∶20,V/V),UV detection wave length of265nm,flow rate of0.8ml/min.RESULTS:
The linear coverage of Riluzole was5~1000ng/ml;the lowest detectable concentration was5ng/ml.The average recoveries of riluzole were99.51%,95.74%and97.12respectively.The within-day and between-day relative standard deviations were1.17%、6.48%(n=5)respectively.CONCLUSION:
The met_ hod is sensitive,accurate,simple and reliable,and it can be applied to phamacokinetic studies.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Document type:
Article