The dynamic changes of antithrombase and Dbrinolytic function in the critical patients / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the dynamic change of the antithrombase and fibrinolytic function in the critical patients.Methods Eighty-seven patients hospitalized in ICU were studied. According to the clinical manifestation, all patients were divided into systemic inflammatory response syndrome (SIRS) group ( n = 68) and non-SIRS group ( n = 19), or multiple organ dysfunction syndrome (MODS) group ( n = 37) and non-MODS group (n = 50) respectively. Thirty-one healthy volunteers were selected for control in the same period. The intravenous blood samples were taken 1,3 and 5 days after ICU admission to measure platelet,count (PLT) , and the plasma levels of antithrombase activity (AT A), plasminogen activity (PLG A), fibrinogen (FIB) and D-dimer (D-D) concentrations.Results AT A, PLG A and PLT were lower and FIB and D-D levels higher in all patients than control levels (P