Effect of Eating on Pharmacokinetics of Ethanesulfonic Acid Levofloxacin Tablets / 中国药房
China Pharmacy
; (12)1991.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-526725
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the effect of eating on pharmacokinetics of ethanesulfonic acid levofloxacin tablets.METHODS:
The blood concentration of 10 healthy male subjects were determined by HPLC after receiving single oral dose of 200mg ethanesulfonic acid levofloxacin both before and after eating by randomized crossover way.The data processing was conducted with 3p97 software so as to figure out the pharmacokinetic parameters.RESULTS:
The plasma concentration-time curves of the subjects after administration of drugs were in conformity with two-compartment model.The respective main pharmacokinetic parameters of the eating group and the empty stomach group were as follows Cmax were (1.91?0.36)mg/L and(2.16?0.69) mg/L; AUC0~t were (14.14?2.32)(mg?h)/L and(14.40?3.11)(mg?h)/L; t1/2? were(6.59?1.66)h and(6.94?0.81 )h.CONCLUSION:
Neither eating nor empty stomach has effect on the pharmacokinetics of ethanesulfonic acid levofloxacin tablets.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Document type:
Article