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Significance of expression of thrombospondin-1 and receptor-CD36 in hepatocellular carcinoma / 中国病理生理杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-526856
Responsible library: WPRO
ABSTRACT

AIM:

To study the expression of thrombospondin-1 (TSP-1) and receptor-CD36, and investigate the relationship between tumor invasive capability and microvessel density and thrombospondin-1.

METHODS:

43 hepatocellular carcinoma (HCC) cases were under investigation. Tissues from tumor, corresponding adjacent non-HCC tissue were stained with CD34 to show the MVD. TSP-1 and CD36 were examined by immunohistochemistry (SP) and RT-PCR. Relationship between clinical pathological features and above parameters was analyed.

RESULTS:

The staining of TSP-1 in HCC tissue is significantly lower than that in corresponding adjacent non-HCC tissue. Expression of TSP-1 was correlated to tumor thrombi, capsule, tumor invasive capability and CD36. CD36 was also correlated to tumor thrombi and tumor invasive capability. MVD was significantly higher in TSP-1, CD36 positive group than that in negative group.

CONCLUSION:

TSP-1 inhibits the growth, invasion and angiogenesis in HCC. TSP-1 may take effect through CD36.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 1986 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 1986 Document type: Article
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