Proton MR spectroscopy in multiple sclerosis:a preliminary study / 中国医师进修杂志

ABSTRACT

Objective To study the characteristics and the regularities of the metabolites in multiple sclerosis(MS) with proton MR spectroscopy, and to investigate the clinical value of MR spectroscopy in multiple sclerosis. Methods The findings of conventional MRI and of ~1HMRSI from 8 cases of acute and chronic multiple sclerosis as and from 12 normal volunteers were comparatively analyzed, its all were using Philips Intera Nova Dual 1.5T MR system. Results ~1HMRSI of all multiple sclerosis as revealed different spectral peaks, including reduced N-acetylaspartate (NAA), creatine (Cr)and NAA/Pcr, prominent phosphorcreatine (Pcr),prominent choline (Cho), prominent lactate,(Lac), and prominent myoinositol (MI) in the acute MS. Normal Cho、Cr、Pcr、MI,void Lip reduced NAA and NAA/Pcr, in the chronic MS. Conclusion MRS is a noninvasive and accurate procedure ,it can reveal organic metabolizability and have capacious foreground.