Dual effects of antithrombin Ⅲ on inflammatory factor and blood coagulatory factor in rats with hemorrhagic shock / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1989.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-528139
Responsible library:
WPRO
ABSTRACT
AIM:
To observe the changes of inflammatory factors and blood coagulatory factors and effects of antithrombin Ⅲ (ATⅢ) on activated inflammatory factors and blood coagulatory factors in rats with hemorrhagic shock.METHODS:
The rat model of hemorrhagic shock was set up. 40 SD rats were randomized into four groups sham operation, shock, routine dose ATⅢ and high dose ATⅢ groups, each group was composed of 10 SD rats. Shock group was administered common resuscitation fluid, routine dose ATⅢ group was administered ATⅢ 20 U/kg, high dose ATⅢ group was administered ATⅢ 100 U/kg everyday for successive three days. Plasma NF-?B, 6-Keto-prostaglandinF1?, E-selectin, sICAM-1, thrombin-ATⅢ complexes, thrombinogen fragment F1+2 (PF F1+2), D-dimer and TMD levels were detected.RESULTS:
Plasma NF-?B, sICAM-1, E -selectin levels were significantly lower in high dose ATⅢ group than those in shock group and routine dose ATⅢ group (P
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1989
Document type:
Article