Determination of Dolasetron Mesylate by HPLC / 中国药房
China Pharmacy
; (12)2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-529319
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To establish a HPLC method for the determination of dolastron mesylate.METHODS:
The sample was separated on Diamonsil C18 column.The mobile phase consisted of acetonitrile-water-1mol? L-1 ammonium formate(450∶ 440∶ 110)(pH=8.0 adjusted with trithylamine)with a flow rate of 1.0mL? min-1.The UV detection wavelength was set at 285nm and the sample size was 20? L.RESULTS:
The linear range of dolasetron mesylate was 24~ 56? g? min-1(r=0.999 6),with average recovery at 99.7%(RSD=0.74%).CONCLUSION:
The established is simple,sensitive and reproducible,and suitable for the quality control of dolasetron mesylate.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Document type:
Article