Retinal Changes of Intravitreal Triamcinolone Acetonide: a Pathohistological Study / 昆明医科大学学报

ABSTRACT

Objective To investigate the effect of triamcinolone acetonide(TA) with different dosage and place of production on retina.Methods Twenty-four rabbits were divided into 6 groups(Auntreated as a blank control;B normal sodium;C10mg imported TA;D10 mg domestic-made TA;E25 mg imported TA;F25 mg domestic-made TA).Excepting group A every right eyeball underwent vitrectomy before intravitreal injection triamcinolone acetonide.All the eyeballs were extirpated on the 21st day after the intravitreal injection,and then pathological examinations were performed.Results Ganglion cell's light edemata had been seen in group B,C,D,E,F.Cell hyperplasia and vacuolar degeneration had been seen in the internal granular layer or external granular layer in some animals of group E,F.Two samples(1 in group E,1 in group F)observed there were a great amount of fibrinoid materials in cavum vitreum and cavum between amphiblestroid membrane and choroid membrane.Pathological changes in group E,F were severer than in group C,D.Conclusions Intravitreous injection TA at 25 mg can cause photoreceptor cells hyperplasia in rabbits,while there are no toxic effects at 10 mg.No obvious difference is observed between the groups of imported TA and domestic-made TA.