Anti-tumor and Anti-mutation Effects of Shenlian Granules / 中国药房

ABSTRACT

OBJECTIVE:To study the anti-tumor and anti-mutation effects of Shenlian granules. METHODS:The anti-mutation effect of Shenlian granules was tested by marrow cell micronucleus test and didymus chromosomal aberration test in mice, and the inhibitory effect of which on S180 and H22 grafting tumor was invesgated as well. RESULTS:Shenlian granules showed significant inhibitory effect on mutation of marrow cell micronucleus caused by cyclophosphamide and aberration of didymus chromosomal cell of mice caused by mitomycin as well as grafting tumor growth of S180 and H22. CONCLUSION:Shenlian granules can prevent DNA of both body cells and germ cells from damage but also inhibit grafting tumor growth in mice.