Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
Experimental & Molecular Medicine
; : 333-347, 2006.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-53157
Responsible library:
WPRO
ABSTRACT
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis. In the central nervous system, microglia, the resident innate immune cells play major role in the inflammatory process. Although they form the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly toxic to neurons by releasing various substances such as inflammatory cytokines (IL-1beta, TNF-alpha, IL-6), NO, PGE
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Signal Transduction
/
Cytokines
/
AIDS Dementia Complex
/
Microglia
/
Inflammation Mediators
/
Matrix Metalloproteinase 3
/
Metalloproteases
/
Encephalitis
/
Alpha-Synuclein
Type of study:
Etiology study
Limits:
Animals
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2006
Document type:
Article