Application of Arginine-enriched Total Parenteral Nutrition in Surgical Nutrition Support / 中国药房

ABSTRACT

OBJECTIVE:To evaluate the effects of arginine-enriched total parenteral nutrition(TPN)on the nutritional and immune parameters of patients undergoing abdominal surgery.METHODS:67 patients undergoing abdominal surgery were randomly assigned to receive routine TPN(control group,n=24),TPN plus 15 g arginine(n=25,trial group Ⅰ)or TPN plus 30 g arginine(n=18,trial group Ⅱ)for 3 days postoperatively.RESULTS:Arginene-enriched TPN significantly improved postoperative nitrogen balance,promoted the recovery of plasma-albumin and total protein,and elevated the levels of CD4+ and CD4+/CD8+,but no significant difference was noted for immunoglobulin,complement C3 and complement C4 during trial period.CONCLUSION:Arginene-enriched TPN can improve patients' postoperative nutritional and immune parameters and enhance the efficacy of TPN support.