Protective Effect of Ethyl Acetate Extract from Oenanthe stolonifera against Myocardial Ischemia and Ischemia-reperfusion Injury in Rats / 中国药房

ABSTRACT

OBJECTIVE:To study the protective effect of ethyl acetate extract from Oenanthe stolonifera against myocardial ischemia and ischemia reperfusion injury in rats.METHODS:Acute myocardial ischemia and ischemical reperfusion injury models were prepared by suture-occluded method.5 min before the onset of ischemia,the rats were injected with ethyl acetate extract from O.stolonifera,then the dynamic ECG change of rats was observed,and the arrhythmia caused by myocardial ischemia and the myocardial infraction size,the arrhythmia induced by myocardial ischemia-reperfusion,the activity of superoxide dismutase(SOD)and the content of malondialdehyde(MDA)in plasma were determined.RESULTS:Ethyl acetate extract from O.stolonifera significantly inhibited myocardial ischemia-induced arrhythmia and decreased the myocardial infarction size,significantly inhibited arrhythmia induced by myocardial ischemia-reperfusion,enhanced SOD activity and decreased the content of MDA in plasma.CONCLUSION:The protective effect of ethyl acetate extract from O.stolonifera against myocardial ischemia and ischemical reperfusion injury in rats is possibly associated to its anti-peroxidation effect.