Content Determination of Residual Organic Solvents in Artesunate by Capillary GC / 中国药房
China Pharmacy
; (12)2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-534054
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To establish capillary GC method for the determination of residual organic solvents in artesunate,such as methanol and ethyl acetate.METHODS:
Capillary GC was adopted and the temperature of flame ionization detector was 250℃.RESULTS:
The linear range were 0.03~0.605 mg?mL-1 for methanol(r=0.999 8) and 0.05~1.002 mg?mL-1 for ethyl acetate(r=0.999 7).The average recovery rates were 98.7% for methanol(RSD=3.0%) and 99.1% for ethyl acetate(RSD=2.1%).Only the ethyl acetate was detected in samples.CONCLUSION:
Established method is simple and accurate for the content determination of residual organic solvents in artesunate.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Document type:
Article