Study of the protective effect of low molecular weight heparin on lung injury in severe acute pancreatitis in rats / 中国普通外科杂志

ABSTRACT

Objective To investigate the protective efficiency of low molecular weight heparin (LMWH) on lung injury in severe acute pancreatitis (SAP).Methods SD rats were randomly divided into 3 groups(1) Sham operation (S) group,(2) SAP group,(3) LMWH treatment (LT) groupLMWH was administrated 4 hours after SAP model was constructed.The levels of serum amylase,endothelin1(ET-1),tumor necrosis factor ? (TNF-?),lung wet/dry weight ratios,pulmonary morphology,the expressions of P65mRNA and P65 protein in pulmonary specimens were detected at 1d after the models were set up,and the 3 days survival rate in each group was also observed.Results (1) The levels of serum amylase,TNF-?,ET-1 in SAP group were significantly increased than those in S group and LT group (all P