Urinary interleukin-8 and pH changes after intravesical bacillus calmette-guerin therapy for superficial bladder cancer:processing and prognostic value / 中华泌尿外科杂志

ABSTRACT

Objective To screen for nonresponding cases of superficial transitional cell carcinoma of the bladder at an early stage of intravesical bacillus Calmette Guetin(BCG) therapy. Methods IL 8 and urine pH were assayed both before intravesical BCG instillation and after the 1st and 6th instillation for 32 cases of superficial transitional cell bladder cancinoma following TURB or partial cystectomy.Urinary IL 8 was measumed by chemiluminescence enzyme immunomeric assay and urine pH by routine examination.The result was studied with reference to the clinical outcome of the patients. Results All the patients have been followed up for 6～25 months with tumor recurrence in 5.Urinary IL 8 in these 5 dropped to 161.3?64.5 ng/L after the 1st instillation whereas it was 579.4?77.8 ng/L in the others ( P