Progress on Carcinogenicity of Alga Toxins / 环境与健康杂志
Journal of Environment and Health
; (12)1989.
Article
in Zh
| WPRIM
| ID: wpr-537398
Responsible library:
WPRO
ABSTRACT
Three aspects of advances in study on the carcinogenicity of alga toxins are reviewed in this paper. Water pollution by alga toxins has become a worldwide environmental problem, and special attention has been paid to the potential carcinogenicity of microcystins, the main alga toxin. Results from the study on structure_activity relationship, short_term screening assay in vitro and long_term rodent carcinogenesis bioassay all showed that alga toxins possessed tumor_promoting activities. It suggested that inhibition of protein phosphatase activities, induction of expression changes of cell proliferation_related genes, dysregulations of signal transduction and cell proliferation might be the mechanisms of the carcinogenesis effect of alga toxins.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Environment and Health
Year:
1989
Document type:
Article