A study on the clinical significance of plasma adrenomedullin and brain natriuretic peptide levels in the elderly patients with chronic cor pulmonale / 中华老年医学杂志

ABSTRACT

Objective To study the clinical significance of plasma adrenomedullin (ADM) and brain natriuretic peptide (BNP) levels in the elderly patients with chronic cor pulmonale. Methods The levels of ADM and BNP in plasma of the elderly patients with chronic cor pulmonale (39 cases in the acute stage and 30 cases in remission stage) were detected by radioimmunoassay. Their correlations with PaO 2,ET-1 and the ratio of right ventricular pre-ejection period to the pulmonary flow acceleration time (RVPEP /AT), which reflected the degree of pulmonary hypertension, were investigated. 27 elderly healthy subjects served as a normal control group. Results The levels of ADM and BNP in the acute and remission stages of cor pulmonale groups were both significantly higher 〔(27.31?6.27)ng/L,(17.22?4.15)ng/L and (66.21?12.79)ng/L,(52.74?8.85)ng/L, respectively〕 than those in the normal control group〔(11.18?3.95)ng/L, (34.52?3.34)ng/L, respectively〕. The levels of ADM and BNP in the acute stage were both significantly higher than those in the remission stage (all P0.05). Conclusions The study suggests that ADM and BNP involve in the pathophysiological process of chronic cor pulmonale in the elderly patients and may play a compensatory role in the disease.