The dose-effect relationship between active DNA and SLE-like syndrome and its characteristic / 中国免疫学杂志
Chinese Journal of Immunology
; (12)1985.
Article
in Zh
| WPRIM
| ID: wpr-537692
Responsible library:
WPRO
ABSTRACT
Objective:To study the relationship between the dose of active DNA and the induction of SLE-like syndrome.Methods: DNA from extracted ConA-activated spleen lymphocytes and immunized syngenic mice with different quantities of active DNA, the anti-dsDNA antibodies and anti-histone antibodies as well as the antibody subclass were detected by ELISA.The patterns of antinuclear antibodies and immune complexes in glomeruli were observed by immunofluorescent-stain. Results: 10 pig active DNA could induce all the animal to produce anti-dsDNA and anti-histone antibodies,and the induced autoann'bodies were mainly IgGl type.Only 25%animals produced autoantibodies immunized by 5 fjig active DNA. Conclusion:The minimum dose of active DNA to induce SLE-like syndrome was 10
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
1985
Document type:
Article