Association of polymorphism of CTLA-4 gene exon 1 with Graves′ disease in Chinese population / 中华内分泌代谢杂志

ABSTRACT

The polymorphism of cytotoxic T lymphocyte associated antigen-4 (CTLA-4) was investigated by PCR-RFLP in 28 healthy volunteers and 64 patients with Graves′ disease (GD). The result suggests that the frequency of G49 allele of CTLA-4 exon 1 in GD patients issignificantlyhigherthanthat in normal controls (P