Effect of FTY720 on the expression of hypoxia inducible factor-1 in rat renal ischemia reperfusion injury / 中华器官移植杂志

ABSTRACT

Objective To investigate the role of FTY720 in the protection of rat renal ischemia reperfusion (I/R) injury and its influence on the expression of hypoxia inducible factor-1? (HIF-1?).Methods Ischemia/reperfusion kidney injury rat model was established. The rats were allocated into groups at random sham group (Sham) and ischemia/reperfusion group (Control). The latter were sub-divided into FTY720 (1 mg/kg every day for 3 days before operation) group, MMF (20 mg/kg every day for 3 days before operation) group and CsA (10 mg/kg every day for 3 days before operation) group. Blood creatinine and the expression levels of HIF-1? mRNA and protein were observed 0 h, 6 h, 24 h, 72 h and 7 days after operation.Results At time points of 0 h , 6 h , and 24 h, Scr levels were higher in FTY720 group than in control group (P