Experimental study on inducement of rat small bowel trans-plantation tolerance by immature dendritic cell cultivated and expansed in vitro / 中国现代普通外科进展
Article
in Zh
| WPRIM
| ID: wpr-547078
Responsible library:
WPRO
ABSTRACT
Objective: To discuss the feasibility of immune tolerance in rat small bowel trans-plantation induced by immature dendritic cells isolated from SD and Wistar rat. Methods: Dendritic cells isolated from liver or bone marrow of inbred strain Wistar and SD rat were cultured for five to nine days. A week before operation, the recipient rats were injected 2?106 inmature DCs from vena dorsalis penis and observed. The models of heterotopic small bowel transplantation (SBT: SD→ Wistar)were established. Acute immuno- rejection levels were evaluated by HE. Results: Varying degrees of rejection were observed in 3, 5, 7 days after operation. Conclusion: Immature DC can induce allogenic immunological tolerance of rat small bowel transplantation.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
1998
Document type:
Article