Differences in angiogenesis and its maturation of hepatocellular carcinoma between in tumor periphery and in center / 中国现代普通外科进展
Article
in Zh
| WPRIM
| ID: wpr-547166
Responsible library:
WPRO
ABSTRACT
Objective:To study the differences in angiogenesis and its maturation between the periphery and center. of hepatocellular carcinoma (HCC). Methods:Thirty-one cases proved surgically and pathologically were selected. After surgery, two sections were gotten from the tumor periphery and center. Continuous slices were stained with immunohistochemistry of five antibodies against VEGF, Flk-1, PCNA.The expressions of VEGF,Flk-1, and PCNA, and some vascular parameters were counted including the number, mean area, total area, circumference, diameter, distance between adjacent vessels(DAV), variety index of microvessel and mature vessels. The arterioles , veinlets, mature vessel index and mean perfused fraction (mPF)were also calculated. The differences of the vascular parameters above between the periphery and center were analyzed. Results: The differences in the number, diameter, and variety index of microvessel, the number and total area of mature vessel, the arterioles and the ratio of arteriole or veinlet, mature vessel index and mPF were statistical differences between the periphery and center of the tumor (P
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
1999
Document type:
Article