Research progresses on relationship between Wnt inhibitory factor-1 and tumor / 中国癌症杂志
China Oncology
; (12)1998.
Article
in Zh
| WPRIM
| ID: wpr-548594
Responsible library:
WPRO
ABSTRACT
WIF-1 is an important antagonist in the Wnt/?-catenin pathway.As a tumor suppressor, WIF-1 is down-regulated in majority cancers but when it is correlated with WIF-1 promoter hypermethylation and treated with demethylation drug, its expression can be restored.Functional loss of WIF-1 due to promoter hypermethylation plays an important role in a tumor's pathogenesis, possibly mainly through aberrant canonical Wnt/?-catenin signal activation.The correlation of the expression of WIF-1 with clinicopathological features in different cancers is not identical.Detecting WIF-1 and promoter hypermethylation may offer help for early diagnosis, therapy and predicting prognoses.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
/
Screening_studies
Language:
Zh
Journal:
China Oncology
Year:
1998
Document type:
Article