Protective Effect of WR-2721 and Fetal Liver Cell Transplantation on Combined Radiation-Burn Injury in Mice / 第三军医大学学报

ABSTRACT

Mice inflicted with severe combined radiation-burn injury were treated with WR-2721 and allogenic fetal liver cell transplantation. The mortality of the treated group was significantly lower and the mean survival time longer than the control. When compared w'th those of the control, the changes of the per pheral white count, the count of the nucletaed cells of the bone marrow, and the bone marrow CFU-C of the treated group were less marked and returned to normal more rapdly. The changes of the peripheral T-lymphocyte count was not so marked as that of the bone marrow CFU-C.The combined therapeutic efficacy of WR-2721 and fetal cell transplantation was more prominant in treating the combined radiation and burn injury than either of the two agents used alone.