Effects of TFP-87 on Hemopoietic Function of Mice with Combined Radiation-Burn Injury / 第三军医大学学报

ABSTRACT

Healthy adult mice were inflicted with combined injury of gamma radiation(4 Gy from a 60Co source) and burns (15% TBSA third degree).From 6 daysprior to to 8 days after the injury.TEP-87,which consists of zinc,copper andiron in the dosage appropriate to the physiological requirement as well as lycine,vitemins B1,B2,C and D,folic acid and malt,was administered.It was found that the protective effect of this preparation on the marrow cells of the myeloblastic line of the animals inflicted with either simple radiation injury or combined injury of radiation and burns was obvious even on the first day after injury.Meanwhile,the total number of white blood cells was maintained at a relatively high level.On the 8th day after injury,accelerated rate of recovery of the mice was observed.No favorable effect could be revealed on the uncleated cells of the bone marrow,or on the positive rate of esterase which is a nonspecific marker of T-lymphocytes.The protective effects of TEP-87 on the hemopoietic function of the mice with combined radiation-burn injury might be due to the direct stimulation of zinc,copper and iron on the proliferation of the hemopoietic stem cells.