EFFECT OF ADRIAMYCIN ON HEART PEROXIDATION IN MICE / 中国药理学通报

ABSTRACT

In mice, adriamycin (l7.5mg/kg, ip ) produced heart peroxida-tion abnormality including increased TBA value & decreased gluta-thione peroxidase activity, respectively. But the change of former was not parallel to the latter. The drug also produced early pathological change of the heart i.e. more D-PAS positiveness. The results suggested that the early heart pathological change produced by adriamycin may be related to increased accumulation of pero-xi dative products.