THE INFLUENCES OF AMMONIUM GLYCYRRHIZANATE AGON PROSTAGLANDIN(PG) AND DNA BIOSYNTHESIS IN CULTURED RAT AND HUMAN LYMPHOCYTES / 中国药理学通报

ABSTRACT

The influences of varied concentrations of AG on the 8H-TdR(3H-Thymidine ) incorporation inhibition rate and the release of PGI2 and TXA2 were studied in cultured human and rat lymphocytes . The results indicated that the AG increased the 3H-TdR incorporation inhibition rate on the concentrations of 1.5? 10-7mol/L and 3?10-7mol/L. Using the RIA method, authors find that AG on the concentrations of 4 ? 10-7mol/L, 4 ? 10-3mol/L and 4 ? 10-11mo/L can significantly decrease the cultured lymphocytes TXA2 release while has no clear influences on PGI2 release