Effects of artesunate on the hepatic GSH content in normal and hepatotoxin-poisoned mice / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-551032
Responsible library:
WPRO
ABSTRACT
This study was undertaken to examine the possible effects of Artesunate(Art) on the hepatic reduced glutathione(GSH) content in normal and hepatotoxin - poisoned mice. It was demonstrated that Art given ip( 100mg?kg-1or 200mg?kg-1 ? 3)to mice had a signifcant protection against hepatic GSH deplection induced by acetaminophen and yellow phosphorus, andthat Art also caused a marked increase of the hepatic GSH content in fasting mice at the dose of 200mg ? kg-1. These results indicate that Art can help the liver detoxication of toxic metabolits in mice.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1987
Document type:
Article